Immuno-stimulators are chemical compounds that can be drugs or nutrient substitutes that induce resistance in the human body by encouraging stimulation or increasing activity of any of its mechanisms. Immune-stimulants are broadly classified into specific immune-stimulants and non-specific immune stimulants. Specific immune-stimulants deliver antigenic specificity in immune response, while non-specific immune-stimulants act without considering the antigenic specificity. Immune check activators are induced to enhance the activity of an immune systems over the antigen. There are no specific approved immune check activators available in the market, with over 20 molecules under clinical trials.
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Cancer immunotherapy specifically target the immune system, in order to trigger a response to destroy tumors cells. Various diverse approaches are in use and few are undergoing research and trials. Randomized controlled trials in various cancers result in exceptional survival rate and decrease in reoccurrence. Efficacy is further improved by 20–30%, when a cell-based immunotherapy is used in conjunction with conservative treatment approaches. The cells destroy the tumor cells that express the antigen when G-CSF lymphocytes are extracted from the blood and growing in-vitro in contradiction to a tumor antigen.
GlaxoSmithKline Pharmaceuticals and Genentech are much focused on investment for research and development in immune activation methodology
Regional segmentation of the immune check activators market by Coherent Market Insights comprises North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. North America accounts for the largest share in the global market, mainly due to presence of major players and adoption of advanced research technologies in countries such as the U.S. and Canada. Increase in cancer prevalence globally is the prominent factor projected to boost growth of the market of immune check activators during the forecast period (2016–2024). Increase in government support and funding towards clinical trials on development of new drugs for cancer therapy also inspires the investigators in developing novel drugs. For instance, as of 2012 U.S. Department of Human Health and Services and National Cancer Institute raised funds of around US$ 5.1 billion to develop cancer drugs
Large number of clinical trial molecules in pipeline to boost growth of Immune check activators market
Key players operating the Immune check activators market include Genentech, Bristol-Myers Squibb, Checkpoint Therapeutics, Inc., GlaxoSmithKline Pharmaceuticals, Hoffmann-La Roche, ImmuNext, Celldex Therapeutics, Inovio Pharmaceuticals, Inc., Genmab, Eutilex Co. Ltd, and Enumeral among others.
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